抄録
Although serotonin has been reported to play a susbstantial role in cardiopulmonary dysfunction, the quantitative effects of serotonin, released from activated platelets, on the development of alveolar flooding and on impaired gas exchange in pulmonary embolism have not been systematically investigated. To elucidate the effects of serotonin on pulmonary hemodynamics, accumulation of edema fluid in alveolar space, and impairment of gas exchange in acute pulmonary embolism, 20 mongrel dogs were given 0.4- 0.6 g/kg of glass beads with a diameter of 100 μm, via the internal juglar vein. Before and after embolization, pulmonary hemodynamics, systemic hemodynamics, blood gases, and the distribution of ventilation-perfusion ratios (V̇(A)/Q̇) in the lung were measured, with and without a newly developed selective antagonist of the serotonin S2 receptor, DV-7028. V̇(A)/Q̇ distribution was determined by applying the multiple inert gas elimination technique. After glass bead embolization, the animals that did not receive DV-7028 showed significant increases in pulmonary arterial pressure and in extravascular lung water, widened alveolar-arterial O2 tension differences, and appreciable development of low V̇(A)/Q̇ areas (0 < V̇(A)/Q̇ ≤ 0.1). These changes were prevented in the animals that received DV-7028. However, DV-7028 did not affect the formation of high V̇(A)/Q̇ areas (V̇(A)/Q̇ > 10). In conclusion, in acute canine pulmonary embolism serotonin not only induces pulmonary hypertension and pulmonary edema, but also worsens gas exchange through the formation of low V̇(A)/Q̇ areas.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 947-955 |
| ページ数 | 9 |
| ジャーナル | Japanese Journal of Thoracic Diseases |
| 巻 | 33 |
| 発行部数 | 9 |
| 出版物ステータス | Published - 1995 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
これを引用
Role of serotonin in impaired gas exchange during pulmonary embolism. / Kawai, A.; Umeda, A.; Mori, Masaaki; Takasugi, T.; Asano, K.; Tanaka, T.; Yasuoka, M.; Yamaguchi, K.
：: Japanese Journal of Thoracic Diseases, 巻 33, 番号 9, 1995, p. 947-955.研究成果: Article
}
TY - JOUR
T1 - Role of serotonin in impaired gas exchange during pulmonary embolism
AU - Kawai, A.
AU - Umeda, A.
AU - Mori, Masaaki
AU - Takasugi, T.
AU - Asano, K.
AU - Tanaka, T.
AU - Yasuoka, M.
AU - Yamaguchi, K.
PY - 1995
Y1 - 1995
N2 - Although serotonin has been reported to play a susbstantial role in cardiopulmonary dysfunction, the quantitative effects of serotonin, released from activated platelets, on the development of alveolar flooding and on impaired gas exchange in pulmonary embolism have not been systematically investigated. To elucidate the effects of serotonin on pulmonary hemodynamics, accumulation of edema fluid in alveolar space, and impairment of gas exchange in acute pulmonary embolism, 20 mongrel dogs were given 0.4- 0.6 g/kg of glass beads with a diameter of 100 μm, via the internal juglar vein. Before and after embolization, pulmonary hemodynamics, systemic hemodynamics, blood gases, and the distribution of ventilation-perfusion ratios (V̇(A)/Q̇) in the lung were measured, with and without a newly developed selective antagonist of the serotonin S2 receptor, DV-7028. V̇(A)/Q̇ distribution was determined by applying the multiple inert gas elimination technique. After glass bead embolization, the animals that did not receive DV-7028 showed significant increases in pulmonary arterial pressure and in extravascular lung water, widened alveolar-arterial O2 tension differences, and appreciable development of low V̇(A)/Q̇ areas (0 < V̇(A)/Q̇ ≤ 0.1). These changes were prevented in the animals that received DV-7028. However, DV-7028 did not affect the formation of high V̇(A)/Q̇ areas (V̇(A)/Q̇ > 10). In conclusion, in acute canine pulmonary embolism serotonin not only induces pulmonary hypertension and pulmonary edema, but also worsens gas exchange through the formation of low V̇(A)/Q̇ areas.
AB - Although serotonin has been reported to play a susbstantial role in cardiopulmonary dysfunction, the quantitative effects of serotonin, released from activated platelets, on the development of alveolar flooding and on impaired gas exchange in pulmonary embolism have not been systematically investigated. To elucidate the effects of serotonin on pulmonary hemodynamics, accumulation of edema fluid in alveolar space, and impairment of gas exchange in acute pulmonary embolism, 20 mongrel dogs were given 0.4- 0.6 g/kg of glass beads with a diameter of 100 μm, via the internal juglar vein. Before and after embolization, pulmonary hemodynamics, systemic hemodynamics, blood gases, and the distribution of ventilation-perfusion ratios (V̇(A)/Q̇) in the lung were measured, with and without a newly developed selective antagonist of the serotonin S2 receptor, DV-7028. V̇(A)/Q̇ distribution was determined by applying the multiple inert gas elimination technique. After glass bead embolization, the animals that did not receive DV-7028 showed significant increases in pulmonary arterial pressure and in extravascular lung water, widened alveolar-arterial O2 tension differences, and appreciable development of low V̇(A)/Q̇ areas (0 < V̇(A)/Q̇ ≤ 0.1). These changes were prevented in the animals that received DV-7028. However, DV-7028 did not affect the formation of high V̇(A)/Q̇ areas (V̇(A)/Q̇ > 10). In conclusion, in acute canine pulmonary embolism serotonin not only induces pulmonary hypertension and pulmonary edema, but also worsens gas exchange through the formation of low V̇(A)/Q̇ areas.
KW - Extravascular lung water
KW - Pulmonary embolism
KW - Pulmonary hypertension
KW - Serotonin
KW - V̇(A)/Q̇ distribution
UR - http://www.scopus.com/inward/record.url?scp=0028839745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028839745&partnerID=8YFLogxK
M3 - Article
C2 - 8538090
AN - SCOPUS:0028839745
VL - 33
SP - 947
EP - 955
JO - Respiratory Investigation
JF - Respiratory Investigation
SN - 2212-5345
IS - 9
ER -