Role of the innate immune system in the development of chronic colitis

Takanori Kanai, Ryoichi Iiyama, Takahiro Ishikura, Koji Uraushihara, Teruji Totsuka, Motomi Yamazaki, Tetsuya Nakamura, Mamoru Watanabe

研究成果: Review article査読

16 被引用数 (Scopus)

抄録

Based on Pasteur's work on the microbial nature of fermentation, it was widely believed that the presence of bacteria in the intestine was essential for the life of the host. It has also been known for decades that gut commensal microbes effect the activation and development of the systemic immune system through gut-associated lymphoid tissues (GALT). Recent extensive studies have shown that recognition of microbes is mediated by a set of germline-encoded receptors, Toll-like receptors (TLRs), in mammals. This article reviews the role of the innate immunity system in the development of GALT and the pathogenesis of inflammatory bowel diseases (IBD).

本文言語English
ページ(範囲)38-42
ページ数5
ジャーナルJournal of gastroenterology
37
SUPPL. 14
出版ステータスPublished - 2002 11月 1
外部発表はい

ASJC Scopus subject areas

  • 消化器病学

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