Role of Wnt Signaling in Mouse Fetal Skin Wound Healing

Kento Takaya, Ayano Sunohara, Noriko Aramaki-hattori, Shigeki Sakai, Keisuke Okabe, Hideko Kanazawa, Toru Asou, Kazuo Kishi

研究成果: Article査読

抄録

Wnt proteins secrete glycoproteins that are involved in various cellular processes to main-tain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented. Our previous studies have shown that, in an early-stage mouse fetus, no scarring occurred after cutaneous wounding, and complete regeneration was achieved. In this study, the expression and localization of Wnt proteins in a mouse fetal-wound-healing model and their associations with scar formation were analyzed. Wnt-related molecules were detected by in-situ hybridization, immunostaining, and real-time polymerase chain reaction. The results showed altered expression of Wnt-related molecules during the wound-healing process. Moreover, scar formation was suppressed by Wnt inhibitors, suggesting that Wnt signaling may be involved in wound healing and scar formation. Thus, regulation of Wnt signaling may be a possible mechanism to control scar formation.

本文言語English
論文番号1536
ジャーナルBiomedicines
10
7
DOI
出版ステータスPublished - 2022 7月

ASJC Scopus subject areas

  • 医学(その他)
  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Role of Wnt Signaling in Mouse Fetal Skin Wound Healing」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル