Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila

Kuniaki Saito, Hirotsugu Ishizu, Miharu Komai, Hazuki Kotani, Yoshinori Kawamura, Kazumichi M. Nishida, Haruhiko Siomi, Mikiko C. Siomi

研究成果: Article査読

227 被引用数 (Scopus)

抄録

PIWI-interacting RNAs (piRNAs) protect genome integrity from transposons. In Drosophila ovarian somas, primary piRNAs are produced and loaded onto Piwi. Here, we describe roles for the cytoplasmic Yb body components Armitage and Yb in somatic primary piRNA biogenesis. Armitage binds to Piwi and is required for localizing Piwi into Yb bodies. Without Armitage or Yb, Piwi is freed from the piRNAs and does not enter the nucleus. Thus, piRNA loading is required for Piwi nuclear entry. We propose that a functional Piwi-piRNA complex is formed and inspected in Yb bodies before its nuclear entry to exert transposon silencing.

本文言語English
ページ(範囲)2493-2498
ページ数6
ジャーナルGenes and Development
24
22
DOI
出版ステータスPublished - 2010 11月 15

ASJC Scopus subject areas

  • 遺伝学
  • 発生生物学

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