Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders

Kazue Hashimoto-Torii, Masaaki Torii, Mitsuaki Fujimoto, Akira Nakai, Rachid ElFatimy, Valerie Mezger, Min J. Ju, Seiji Ishii, Shih hui Chao, Kristen J. Brennand, Fred H. Gage, Pasko Rakic

研究成果: Article査読

73 被引用数 (Scopus)

抄録

Prenatal exposure of the developing brain to various environmental challenges increases susceptibility tolate onset of neuropsychiatric dysfunction; still, the underlying mechanisms remain obscure. Here we show that exposure of embryos to a variety of environmental factors such as alcohol, methylmercury, and maternal seizure activates HSF1 in cerebral cortical cells. Furthermore, Hsf1 deficiency in the mouse cortex exposed in utero to subthreshold levels of these challenges causes structural abnormalities and increases seizure susceptibility after birth. In addition, we found that human neural progenitor cells differentiated from induced pluripotent stem cells derived from schizophrenia patients show higher variability in the levels of HSF1 activation induced by environmental challenges compared to controls. We propose that HSF1 plays a crucial role in the response of brain cells to prenatal environmental insults and may be a key component in the pathogenesis of late-onset neuropsychiatric disorders.

本文言語English
ページ(範囲)560-572
ページ数13
ジャーナルNeuron
82
3
DOI
出版ステータスPublished - 2014 5 7
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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