Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments

Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto, Tomoko Iwata-Kajihara, Shoko Nakamura, Hiroshi Nishio, Ryosuke Satomi, Asuka Kobayashi, Mayuri Tanaka, Jeong Hoon Park, Hajime Kamijuku, Takahiro Tsujikawa, Naoshi Kawamura

研究成果: Chapter

3 引用 (Scopus)

抄録

Cancer cells trigger multiple immunosuppressive cascades and generate immunosuppressive tumor-associated microenvironments including tumor and sentinel lymph nodes. Constitutive activation of various signaling pathways (e.g., MAPK, STAT3, NF-κB, β-catenin) in human cancer cells was found to trigger the multiple immunosuppressive cascades through the production of immunosuppressive cytokines, such as TGF-β, IL-10, IL-6, and VEGF, and induction of immunosuppressive immune cells, such as regulatory T cells, tolerogenic dendritic cells, and myeloid derived suppressor cells. Some of these cancer-derived cytokines impair various immune cells through activation of their signaling molecules such as STAT3 and NF-κB. Inhibitors for these activated signals could inhibit the multiple immunosuppressive cascades by acting on both cancer cells and immune cells. Since common signaling mechanisms are often utilized for some of the hallmarks of cancer (e.g., cell proliferation/survival, invasion/metastasis, and immunosuppression), targeting these common signaling pathways may be an attractive strategy for cancer therapy, including immunotherapy.

元の言語English
ホスト出版物のタイトルThe Tumor Immunoenvironment
出版者Springer Netherlands
ページ307-323
ページ数17
ISBN(印刷物)9789400762176, 940076216X, 9789400762169
DOI
出版物ステータスPublished - 2014 1 1

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Tumor Microenvironment
Immunosuppressive Agents
Neoplasms
Cytokines
Catenins
Regulatory T-Lymphocytes
Interleukin-10
Immunotherapy
Immunosuppression
Dendritic Cells
Vascular Endothelial Growth Factor A
Interleukin-6
Cell Survival
Cell Proliferation
Neoplasm Metastasis

ASJC Scopus subject areas

  • Medicine(all)

これを引用

Kawakami, Y., Yaguchi, T., Sumimoto, H., Kudo-Saito, C., Tsukamoto, N., Iwata-Kajihara, T., ... Kawamura, N. (2014). Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments. : The Tumor Immunoenvironment (pp. 307-323). Springer Netherlands. https://doi.org/10.1007/978-94-007-6217-6_12

Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments. / Kawakami, Yutaka; Yaguchi, Tomonori; Sumimoto, Hidetoshi; Kudo-Saito, Chie; Tsukamoto, Nobuo; Iwata-Kajihara, Tomoko; Nakamura, Shoko; Nishio, Hiroshi; Satomi, Ryosuke; Kobayashi, Asuka; Tanaka, Mayuri; Park, Jeong Hoon; Kamijuku, Hajime; Tsujikawa, Takahiro; Kawamura, Naoshi.

The Tumor Immunoenvironment. Springer Netherlands, 2014. p. 307-323.

研究成果: Chapter

Kawakami, Y, Yaguchi, T, Sumimoto, H, Kudo-Saito, C, Tsukamoto, N, Iwata-Kajihara, T, Nakamura, S, Nishio, H, Satomi, R, Kobayashi, A, Tanaka, M, Park, JH, Kamijuku, H, Tsujikawa, T & Kawamura, N 2014, Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments. : The Tumor Immunoenvironment. Springer Netherlands, pp. 307-323. https://doi.org/10.1007/978-94-007-6217-6_12
Kawakami Y, Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Iwata-Kajihara T その他. Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments. : The Tumor Immunoenvironment. Springer Netherlands. 2014. p. 307-323 https://doi.org/10.1007/978-94-007-6217-6_12
Kawakami, Yutaka ; Yaguchi, Tomonori ; Sumimoto, Hidetoshi ; Kudo-Saito, Chie ; Tsukamoto, Nobuo ; Iwata-Kajihara, Tomoko ; Nakamura, Shoko ; Nishio, Hiroshi ; Satomi, Ryosuke ; Kobayashi, Asuka ; Tanaka, Mayuri ; Park, Jeong Hoon ; Kamijuku, Hajime ; Tsujikawa, Takahiro ; Kawamura, Naoshi. / Roles of signaling pathways in cancer cells and immune cells in generation of immunosuppressive tumor-associated microenvironments. The Tumor Immunoenvironment. Springer Netherlands, 2014. pp. 307-323
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