Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

Takashi Sekiya, Hiroko Nakatsukasa, Qianjin Lu, Akihiko Yoshimura

研究成果: Short survey査読

19 被引用数 (Scopus)

抄録

Regulatory T (Treg) cells are an essential cell subset for the maintenance of immune homeostasis. Treg cells are characterized by a distinct pattern of gene expression, including the upregulation of immune-suppressive genes and the silencing of inflammatory genes. The molecular mechanisms involved in the development and maintenance of Tregs have been extensively investigated. We have identified essential transcription factors NR4a and Smad2/3 in the development of thymic Tregs and induced Tregs, respectively. This article reviews the roles of transcription factors in the differentiation, maintenance, and function of Treg cells.

本文言語English
ページ(範囲)378-386
ページ数9
ジャーナルMicrobes and Infection
18
6
DOI
出版ステータスPublished - 2016 6 1

ASJC Scopus subject areas

  • 微生物学
  • 免疫学
  • 感染症

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