Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular–Subventricular Zone

Yuki Hirota, Masato Sawada, Shih hui Huang, Takashi Ogino, Shinya Ohata, Akiharu Kubo, Kazunobu Sawamoto

研究成果: Article査読

12 被引用数 (Scopus)

抄録

In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular–subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/β-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. Here, we review the Wnt signaling-mediated regulation of adult neurogenesis in the V-SVZ under physiological and pathological conditions.

本文言語English
ジャーナルNeurochemical Research
DOI
出版ステータスAccepted/In press - 2015 11 16

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

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