Ropinirole, a New ALS Drug Candidate Developed Using iPSCs

Hideyuki Okano, Daisuke Yasuda, Koki Fujimori, Satoru Morimoto, Shinichi Takahashi

研究成果: Review article査読

21 被引用数 (Scopus)

抄録

Induced pluripotent stem cells (iPSCs) are increasingly used in the study of disease mechanisms and the development of effective disease-modifying therapies for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Recently, three candidate anti-ALS drugs – ropinirole (ROPI), retigabine, and bosutinib – have been identified in iPSC-based drug screens and are now being evaluated in clinical trials for safety and effectiveness. We review the preclinical data, clinical research design, and rationale for ROPI as an anti-ALS drug candidate compared with those of the other two drugs. We also discuss the use of iPSCs for understanding and monitoring treatment response as well as for new insights into the development of new drugs and therapeutic interventions for major neurodegenerative diseases.

本文言語English
ページ(範囲)99-109
ページ数11
ジャーナルTrends in Pharmacological Sciences
41
2
DOI
出版ステータスPublished - 2020 2

ASJC Scopus subject areas

  • 毒物学
  • 薬理学

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