Rostrocaudal areal patterning of human PSC-derived cortical neurons by FGF8 signaling

Kent Imaizumi, Koki Fujimori, Seiji Ishii, Asako Otomo, Yasushi Hosoi, Hiroaki Miyajima, Hitoshi Warita, Masashi Aoki, Shinji Hadano, Wado Akamatsu, Hideyuki Okano

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The cerebral cortex is subdivided into distinct areas that have particular functions. The rostrocaudal (R-C) gradient of fibroblast growth factor 8 (FGF8) signaling defines this areal identity during neural development. In this study, we recapitulated cortical R-C patterning in human pluripotent stem cell (PSC) cultures. Modulation of FGF8 signaling appropriately regulated the R-C markers, and the patterns of global gene expression resembled those of the corresponding areas of human fetal brains. Furthermore, we demonstrated the utility of this culture system in modeling the area-specific forebrain phenotypes [presumptive upper motor neuron (UMN) phenotypes] of amyotrophic lateral sclerosis (ALS). We anticipate that our culture system will contribute to studies of human neurodevelopment and neurological disease modeling.

本文言語English
論文番号e0368-17.2018
ジャーナルeNeuro
5
2
DOI
出版ステータスPublished - 2018 3 1

ASJC Scopus subject areas

  • 神経科学(全般)

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