Salutary antiarrhythmic effect of combining a K channel blocker and a β-blocker in a canine model of 7-day-old myocardial infarction

Seiji Takatsuki, Hideo Mitamura, Hideaki Kanki, Koichiro Sueyoshi, Satoshi Ogawa

研究成果: Article査読

抄録

We sought to examine whether the antiarrhythmic effect of E4031 (E), or I(Kr). channel blocker, is affected by β-adrenergic stimulation using isoproterenol (Iso) or by β-adrenergic blockade (βB) using, ONO1101, in a canine myocardial infarction model. Electrophysiologic studies were performed in 10 dogs with 7-day-old myocardial infarctions. Local QT intervals were measured at 47 sites on the infarcted myocardium using a mapping electrode. QT dispersion (QT(d)), as defined by the coefficient of variation of QT intervals, was obtained. Inducibility of ventricular arrhythmias was examined by programmed stimulation. These procedures were repeated during administration of E, E + Iso, and E+ βB. The effect of prolonging local QT intervals by E was counteracted by Iso, and was accentuated by βB. The amount of prolongation was dependent on the baseline QT intervals, and QT(d) showed a tendency to decrease with E, to increase with E + Iso, and significantly decreased with E + βB. Ventricular tachyarrhythmias were induced in a half of dogs with E + Iso, but were not induced with E + βB. In the presence of adrenergic activation, I(Kr) blockers may exhibit a decreased antiarrhythmic effect. Beneficial synergism can be expected when an I(Kr) blocker is combined with a β-blocker in the subacute phase of myocardial infarction.

本文言語English
ページ(範囲)914-918
ページ数5
ジャーナルJournal of Cardiovascular Pharmacology
35
6
DOI
出版ステータスPublished - 2000 6 13

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

フィンガープリント 「Salutary antiarrhythmic effect of combining a K channel blocker and a β-blocker in a canine model of 7-day-old myocardial infarction」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル