SCE induction in human lymphocytes by combined treatment with aniline and norharman

S. Takehisa, N. Kanaya

研究成果: Article査読

19 被引用数 (Scopus)

抄録

In human blood lymphocytes, aniline was unable to induce an increase of SCEs in vitro with or without metabolic activation by S9 mix. p-Aminophenol, one of the C-hydroxylation metabolites of aniline in the body, however, increased the SCE frequencies of lymphocytes at a concentration of 10-4 M. The addition of norharman to aniline plus S9 mix increased the SCE frequencies. This increase, however, was due to the SCE-inducing activity of norharman. These data show that the addition of norharman, which enhances the sensitivity of the Salmonella/microsome test, does not produce an enhancement of the sensitivity of the SCE test.

本文言語English
ページ(範囲)165-172
ページ数8
ジャーナルMutation Research/Genetic Toxicology
101
2
DOI
出版ステータスPublished - 1982 4

ASJC Scopus subject areas

  • 毒物学
  • 遺伝学

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