Screening, substrate specificity and stereoselectivity of yeast strains, which reduce sterically hindered isopropyl ketones

Chihiro Hiraoka, Masaaki Matsuda, Yuya Suzuki, Shigeo Fujieda, Mina Tomita, Ken ichi Fuhshuku, Rika Obata, Shigeru Nishiyama, Takeshi Sugai

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Towards the synthesis of sterically hindered optically active secondary alcohol 2, yeast strains (Candida floricola IAM 13115 and Trichosporon cutaneum IAM 12206) with si-face hydride attack on isopropyl phenylsulfonylmethyl ketone 1 were developed by screening. Strains with complementary re-facial selectivity (Pichia angusta IAM 12895 and Pichia minuta IAM 12215) were also found. Based on the substrate specificity studies of these four strains, microbial reduction was applied to the synthesis of (3S,5S)-2,6-dimethyl-3,5-heptanediol 12a.

本文言語English
ページ(範囲)3358-3367
ページ数10
ジャーナルTetrahedron Asymmetry
17
24
DOI
出版ステータスPublished - 2006 12 27

ASJC Scopus subject areas

  • 触媒
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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