Selective activation of calcium permeability by aspartate in Purkinje cells

Michisuke Yuzaki, Douglas Forrest, Tom Curran, John A. Connor

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Glutamate and aspartate are endogenous excitatory amino acid neurotransmitters widely distributed in the mammalian central nervous system. Aspartate was shown to induce a large membrane current sensitive to N- methyI-D-aspartate (NMDA) and non-NMDA receptor antagonists in Purkinje cells from mice lacking functional NMDA receptors (NR1(-/-)). This response was accompanied by high permeability to calcium. In contrast, no current was induced by aspartate in hippocampal neurons and cerebellar granule cells from NR1-/- mice. Several other glutamate receptor agonists failed to evoke this response. Thus, in Purkinje cells, aspartate activates a distinct response capable of contributing to synaptic plasticity through calcium permeability.

本文言語English
ページ(範囲)1112-1114
ページ数3
ジャーナルScience
273
5278
DOI
出版ステータスPublished - 1996 8 23
外部発表はい

ASJC Scopus subject areas

  • General

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