Selective inhibition of gastrulation in the starfish embryo by albuside B, an inosine analogue

Takahiko Shimizu, Keiichi Hamada, Haruhiko Isomura, Yuki Myotoishi, Susumu Ikegami, Hiroyuki Kaneko, Marina Dan-Sohkawa

研究成果: Article査読

8 被引用数 (Scopus)

抄録

External application of 0.2-100 μg/ml albuside B inhibits gastrulation of the starfish (Asterina pectinifera) embryo. Treated embryos retain the late blastula morphology with the vegetal plate. However, the vegetal plate is unreactive to soybean agglutinin, a probe for observing the progenitor cells of the archenteron (mesendoderm) in a normal embryo. The effective period of the treatment is limited from 4 to 6 h after fertilization, a period immediately before the onset of blastulation. RNA synthesis is unaffected during the period of sensitivity. The selectivity of the inhibition shows that albuside B may be a useful tool for studying the mechanisms of mesendoderm differentiation.

本文言語English
ページ(範囲)221-224
ページ数4
ジャーナルFEBS Letters
369
2-3
DOI
出版ステータスPublished - 1995 8月 7
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「Selective inhibition of gastrulation in the starfish embryo by albuside B, an inosine analogue」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル