Selective Monoarylation of Aromatic Ketones via C-H Bond Cleavage by Trialkylphosphine Ruthenium Catalysts

Issei Suzuki, Hikaru Kondo, Takuya Kochi, Fumitoshi Kakiuchi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A catalyst system consisting of RuHCl(CO)(PiPr3)2, CsF, and a styrene derivative was found to be applicable to selective monoarylation of aromatic ketones via ortho C-H bond cleavage. The reaction of 2′-methoxyacetophenone with arylboronates gave C-H arylation products without cleaving the ortho C-O bond. Acetophenone was also converted to monoarylation products with high selectivity. Cyclohexanone was found to be an effective solvent for the C-H arylation using the catalyst system.

本文言語English
ページ(範囲)12975-12982
ページ数8
ジャーナルJournal of Organic Chemistry
84
20
DOI
出版ステータスPublished - 2019 10 18

ASJC Scopus subject areas

  • 有機化学

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