TY - JOUR
T1 - Self-Assembling Properties and Recovery Effects on Damaged Skin Cells of Chemically Synthesized Mannosylerythritol Lipids
AU - Kondo, Takanori
AU - Yasui, Chihiro
AU - Banno, Taisuke
AU - Asakura, Kouichi
AU - Fukuoka, Tokuma
AU - Ushimaru, Kazunori
AU - Koga, Maito
AU - Minamikawa, Hiroyuki
AU - Saika, Azusa
AU - Morita, Tomotake
AU - Takahashi, Daisuke
AU - Toshima, Kazunobu
N1 - Funding Information:
This research was supported in part by JSPS KAKENHI Grant Number JP19H02724 in Scientific Research (B) and JST CREST Grant Number JPMJCR20R3.
Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2022/1/19
Y1 - 2022/1/19
N2 - Mannosylerythritol lipids (MELs), which are one of the representative sugar-based biosurfactants (BSs) produced by microorganisms, have attracted much attention in various fields in the sustainable development goals (SDGs) era. However, they are inseparable mixtures with respect to the chain length of the fatty acids. In this study, self-assembling properties and structure-activity relationship (SAR) studies of recovery effects on damaged skin cells using chemically synthesized MELs were investigated. It was revealed, for the first time, that synthetic and homogeneous MELs exhibited significant self-assembling properties to form droplets or giant vesicles. In addition, a small difference in the length of the fatty acid chains of the MELs significantly affected their recovery effects on the damaged skin cells. MELs with medium or longer length alkyl chains exhibited much higher recovery effects than that of C18-ceramide NP.
AB - Mannosylerythritol lipids (MELs), which are one of the representative sugar-based biosurfactants (BSs) produced by microorganisms, have attracted much attention in various fields in the sustainable development goals (SDGs) era. However, they are inseparable mixtures with respect to the chain length of the fatty acids. In this study, self-assembling properties and structure-activity relationship (SAR) studies of recovery effects on damaged skin cells using chemically synthesized MELs were investigated. It was revealed, for the first time, that synthetic and homogeneous MELs exhibited significant self-assembling properties to form droplets or giant vesicles. In addition, a small difference in the length of the fatty acid chains of the MELs significantly affected their recovery effects on the damaged skin cells. MELs with medium or longer length alkyl chains exhibited much higher recovery effects than that of C18-ceramide NP.
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U2 - 10.1002/cbic.202100631
DO - 10.1002/cbic.202100631
M3 - Article
C2 - 34783433
AN - SCOPUS:85119954797
SN - 1439-4227
VL - 23
JO - ChemBioChem
JF - ChemBioChem
IS - 2
M1 - e202100631
ER -