Sensitive detection of alkyne-terminated hydrophobic drug by surface-enhanced stimulated Raman scattering in cetyltrimethylammonium bromide-coated gold nanorod suspensions

Takaha Mizuguchi, Mutsuo Nuriya, Masato Yasui, Takanori Iino, Yasuyuki Ozeki, Toshiharu Saiki

研究成果: Article査読

抄録

We demonstrate the sensitive detection of alkyne-terminated ethinylestradiol (EE2) in a cetyltrimethylammonium bromide (CTAB)-coated gold nanorod (AuNR) suspension by surface-enhanced stimulated Raman scattering (SRS). Since alkynes show a distinct Raman peak at the silent wavenumber region, EE2 can be detected by obtaining the alkyne-specific SRS signals. Here we find the CTAB coating uniformly adsorbs the hydrophobic EE2 and enables it to exist in the plasmonic hotspot of AuNRs without the alkyne binding to AuNR surfaces. As a result, ensemble-averaged plasmonic enhancement using a CTAB-coated AuNR suspension improved the detection limit for SRS signals from EE2 by one order of magnitude.

本文言語English
論文番号032003
ジャーナルApplied Physics Express
14
3
DOI
出版ステータスPublished - 2021 3

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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