Sensitivity analysis of ectopic electrical activity in the pulmonary vein myocardium

Hitomi I. Sano, Yuichiro Tanaka, Yasuhiro Naito, Masaru Tomita

研究成果: Conference contribution

抄録

The pulmonary vein contains a myocardial layer that is capable of generating spontaneous or triggered action potentials. Although the electrophysiological and pharmacological characteristics of the pulmonary vein myocardium have been compiled in various studies, a comprehensive understanding of the spontaneous action potentials generated in the myocardial layer has yet to be presented. Here we integrated the electrophysiological properties of the pulmonary vein myocardial layer using a Guinea pig ventricular cell model. Based on the preceding research, which reported that approximately half of the isolated pulmonary vein myocardial layer exhibited spontaneous action potentials and the remaining half was quiescent, we constructed various combinations of the pulmonary vein myocardial models to represent variations of the action potential tracings. As a result, we predicted that the spontaneous action potentials, including burst-like action potentials, are observed with varying currents of the relative densities of Na+ (INa), L-type Ca2+ (ICaL), inwardly rectifying K+ (IK1), rapid component of delayed rectifying K+ (IKr), and ACh-activated K+ (IKACh).

本文言語English
ホスト出版物のタイトルComputing in Cardiology
出版社IEEE Computer Society
ページ861-864
ページ数4
42
ISBN(印刷版)9781509006854
DOI
出版ステータスPublished - 2016 2 16
イベント42nd Computing in Cardiology Conference, CinC 2015 - Nice, France
継続期間: 2015 9 62015 9 9

Other

Other42nd Computing in Cardiology Conference, CinC 2015
国/地域France
CityNice
Period15/9/615/9/9

ASJC Scopus subject areas

  • 循環器および心血管医学
  • コンピュータ サイエンス(全般)

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