Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system

Kazunari Yoshida, Shinichi Kohsaka, Takeshi Idei, Seiji Nii, Mitsuhiro Otani, Shigeo Toya, Yasuzo Tsukada

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Neurotrophic effects (NTEs) of various brain regions of 4-week-old rats were examined in primary culture of rat embryonic cerebral hemispheres. Extracts of the hippocampus, brainstem and septal nucleus highly enhanced the survivability of neuronal cells and the division of non-neuronal cells by 9 days. The septohippocampal tract (fimbria fornix) was cut and the effect on the neurotrophic activity in the hippocampus was examined. The NTEs of hippocampal extracts remained unchanged 3 days after septal deafferentation, was significantly increased by 7 days, peaked at 14 days and returned to the basal level by 21 days.

本文言語English
ページ(範囲)181-186
ページ数6
ジャーナルNeuroscience Letters
66
2
DOI
出版ステータスPublished - 1986 5月 15
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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