Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population

Tadashi Umekage, Mamoru Tochigi, Tetsuya Marui, Chieko Kato, Hiroyuki Hibino, Toshiyuki Otani, Kazuhisa Kohda, Nobumasa Kato, Tsukasa Sasaki

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78%) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.

本文言語English
ページ(範囲)13-16
ページ数4
ジャーナルNeuroscience Letters
337
1
DOI
出版ステータスPublished - 2003 1 30

ASJC Scopus subject areas

  • 神経科学(全般)

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