Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study

Satomi Maeda, Yasushi Takeya, Ryosuke Oguro, Hiroshi Akasaka, Hirochika Ryuno, Mai Kabayama, Serina Yokoyama, Motonori Nagasawa, Taku Fujimoto, Masao Takeda, Miyuki Onishi-Takeya, Norihisa Itoh, Yoichi Takami, Koichi Yamamoto, Ken Sugimoto, Hiroki Inagaki, Madoka Ogawa, Takeshi Nakagawa, Saori Yasumoto, Yukie MasuiYasumichi Arai, Tatsuro Ishizaki, Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Hiromi Rakugi

研究成果: Article

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Aim: The objective of this study was to clarify the relationship between cognitive function and the serum albumin/globulin ratio (A/G ratio) in community-dwelling Japanese older adults. Methods: Randomly extracted residents in both urban and rural parts of Japan were enrolled in this study. A total of 1827 participants with a mean age of 70 or 80 years were recruited. A venue survey method was carried out with comprehensive studies, including interviews, blood collection, physical examination and cognitive function tests. Results: Univariate analysis showed a significant positive correlation between the total Japanese version of the Montreal Cognitive Assessment score and the serum A/G ratio at the age of 70 and 80 years, in which better cognitive function was associated with a high serum A/G ratio. Multiple regression analysis with the total Japanese version of the Montreal Cognitive Assessment score as the dependent variable showed that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and sex were related to the Japanese version of the Montreal Cognitive Assessment total score at the age of 70 years, and that the serum albumin level, serum globulin level, serum A/G ratio, C-reactive protein, years of formal education and stroke were related at the age of 80 years. The serum A/G ratio showed a better correlation than the serum globulin levels at the age of 70 and 80 years (70 years: β = 0.131 vs –0.111, 80 years: β = 0.108 vs –0.071). Conclusions: We found a correlation between cognitive function and the serum A/G ratio in community-dwelling older people, suggesting that nutritional status and chronic inflammation might influence cognitive function. Geriatr Gerontol Int 2019; 19: 967–971.

元の言語English
ページ(範囲)967-971
ページ数5
ジャーナルGeriatrics and Gerontology International
19
発行部数10
DOI
出版物ステータスPublished - 2019 10 1

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

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    Maeda, S., Takeya, Y., Oguro, R., Akasaka, H., Ryuno, H., Kabayama, M., Yokoyama, S., Nagasawa, M., Fujimoto, T., Takeda, M., Onishi-Takeya, M., Itoh, N., Takami, Y., Yamamoto, K., Sugimoto, K., Inagaki, H., Ogawa, M., Nakagawa, T., Yasumoto, S., ... Rakugi, H. (2019). Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. Geriatrics and Gerontology International, 19(10), 967-971. https://doi.org/10.1111/ggi.13751