Serum level of pigment epithelium derived factor (PEDF) is an independent determinant of resting heart rate in Japanese subjects

Kazuo Nakamura, Sho ichi Yamagishi, Hisashi Adachi, Takanori Matsui, Yayoi Kurita, Hiroyoshi Inoue

研究成果: Article

14 引用 (Scopus)

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We have recently found that serum level of pigment epithelium derived factor (PEDF) is significantly increased in proportion to the accumulation of the number of the components of the metabolic syndrome. Although high heart rate is also associated with metabolic risk factors for atherosclerosis, the correlation between serum level of PEDF and resting heart rate remains to be elucidated. In this study, we examined their relationship in Japanese outpatients. Four hundred two consecutive outpatients at Nakamura Clinic (141 male and 261 female; mean age 74.9 ± 9.9) underwent a complete history and physical examination, determination of blood chemistries and PEDF levels. In multiple regression analysis, smoking (p = 0.003), use of β-blockers (p = 0.010, inversely), presence of atrial fibrillation (p = 0.014), PEDF (p = 0.018) and glucose levels (p = 0.033) were independently correlated to resting heart rate. Further, when mean serum PEDF levels were stratified by resting heart rates, a linear and significant trend (p = 0.025) was observed. The present study demonstrated for the first time that serum level of PEDF was one of the independent determinants of resting heart rate in Japanese outpatients. PEDF may play some role in sympathetic nerve activity.

元の言語English
ページ(範囲)245-247
ページ数3
ジャーナルInternational Journal of Cardiology
136
発行部数2
DOI
出版物ステータスPublished - 2009 8 14
外部発表Yes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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