Serum levels of IFN-inducible protein-10 relating to the activity of systemic lupus erythematosus

Shosaku Narumi, Tsutomu Takeuchi, Yuko Kobayashi, Konosuke Konishi

研究成果: Article査読

98 被引用数 (Scopus)

抄録

IFN-inducible protein-10 (IP-10) is supposed to act as a specific chemoattractant for Th1 cells. Since Th1 cells and IFN-γ are shown to be important for developing systemic lupus erythematosus (SLE), we examined the relationship between serum IP-10 levels and the disease activity. Serum IP-10 levels were markedly increased in the SLE patients depending on the level of disease activity, whereas not in the patients with rheumatoid arthritis (RA). On the other hand, serum MCP-1 levels were increased to a similar extent both in RA and inactive SLE patients, and a little more elevated in active SLE patients. Serum IP-10 levels in SLE patients correlated positively and negatively with levels of anti-DNA antibody and complements, respectively, whereas MCP-1 levels correlated less or not at all. These results suggest that serum IP-10 levels could be a good indicator for the activity of SLE and that IP-10 could play an important immunological role in SLE. (C) 2000 Academic Press.

本文言語English
ページ(範囲)1561-1565
ページ数5
ジャーナルCytokine
12
10
DOI
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 生化学
  • 血液学
  • 分子生物学

フィンガープリント

「Serum levels of IFN-inducible protein-10 relating to the activity of systemic lupus erythematosus」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル