Sex-specific histone modifications in mouse fetal and neonatal germ cells

Yukiko Kawabata, Asuka Kamio, Yuko Jincho, Akihiko Sakashita, Tomoya Takashima, Hisato Kobayashi, Yasuhisa Matsui, Tomohiro Kono

研究成果: Article査読

抄録

Aims: Epigenetic signatures of germline cells are dynamically reprogrammed to induce appropriate differentiation, development and sex specification. We investigated sex-specific epigenetic changes in mouse fetal germ cells (FGCs) and neonatal germ cells. Materials & methods: Six histone marks in mouse E13.5 FGCs and P1 neonatal germ cells were analyzed by chromatin immunoprecipitation and sequencing. These datasets were compared with transposase-accessible chromatin sites, DNA methylation and transcriptome. Results: Different patterns of each histone mark were detected in female and male FGCs, and H3K4me3/H3K27me3 bivalent marks were enriched in different chromosomal regions of female and male FGCs. Conclusion: Our results suggest that histone modifications may affect FGC gene expression following DNA methylation erasure, contributing to the differentiation into female and male germ cells.

本文言語English
ページ(範囲)543-561
ページ数19
ジャーナルEpigenomics
11
5
DOI
出版ステータスPublished - 2019 4
外部発表はい

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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