@article{1036c2baeda5411e9ab79e8090e9b40e,
title = "Sex-specific histone modifications in mouse fetal and neonatal germ cells",
abstract = "Aims: Epigenetic signatures of germline cells are dynamically reprogrammed to induce appropriate differentiation, development and sex specification. We investigated sex-specific epigenetic changes in mouse fetal germ cells (FGCs) and neonatal germ cells. Materials & methods: Six histone marks in mouse E13.5 FGCs and P1 neonatal germ cells were analyzed by chromatin immunoprecipitation and sequencing. These datasets were compared with transposase-accessible chromatin sites, DNA methylation and transcriptome. Results: Different patterns of each histone mark were detected in female and male FGCs, and H3K4me3/H3K27me3 bivalent marks were enriched in different chromosomal regions of female and male FGCs. Conclusion: Our results suggest that histone modifications may affect FGC gene expression following DNA methylation erasure, contributing to the differentiation into female and male germ cells.",
keywords = "ATAC-seq, DNA methylation, epigenetics, fetal germ cells, gene expression, histone modifications, sex differences, transcriptome",
author = "Yukiko Kawabata and Asuka Kamio and Yuko Jincho and Akihiko Sakashita and Tomoya Takashima and Hisato Kobayashi and Yasuhisa Matsui and Tomohiro Kono",
note = "Funding Information: This project was supported by Grants-in-Aid for Scientific Research from the Japanese Science and Technology Agency and by AMED-CREST, #JP17gm0510017h from the Japanese Agency for Medical Research and Development and MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2013–2017 (S1311017) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors have no other relevant affiliations or financial involvement with any organization or entry with a financial interest conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2019 Future Medicine Ltd.",
year = "2019",
month = apr,
doi = "10.2217/epi-2018-0193",
language = "English",
volume = "11",
pages = "543--561",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "5",
}