Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions

Naoya Kumagai, Giovanni Muncipinto, Stuart L. Schreiber

研究成果: Article査読

146 被引用数 (Scopus)

抄録

(Chemical Equation Presented) An efficient synthetic pathway to skeletally and stereochemically diverse molecules is described. Densely functionalized amino alcohols were readily synthesized through a Petasis three-component, boronic acid Mannich reaction. Their intramolecular cyclization provided a collection of diverse single-isomer compounds with 15 different types of skeletons in three to five steps.

本文言語English
ページ(範囲)3635-3638
ページ数4
ジャーナルAngewandte Chemie - International Edition
45
22
DOI
出版ステータスPublished - 2006 5月 26
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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