Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin

Jianing Zhang, Jun Nakayama, Chikara Ohyama, Masami Suzuki, Atsushi Suzuki, Minoru Fukuda, Michiko N. Fukuda

研究成果: Article査読

49 被引用数 (Scopus)

抄録

Endothelial carbohydrate binding proteins, E- and P-selectins, are thought to mediate sialyl Lewis A/X-dependent hematogenous cancer metastasis. We tested this hypothesis using sialyl Lewis X-dependent B16 melanoma lung targeting and its inhibition with selectin ligand mimicry peptide, IELLQAR. In E/P-selectin doubly deficient mutant mice, sialyl Lewis X-expressing B16 melanoma cells colonized the lung, and IELLQAR inhibited this colonization. However, tumors grown in E/P-selectin-deficient mice were significantly smaller than those grown in wild-type mice. These results indicate that the IELLQAR peptide receptor expressed in the lung vasculature plays a major role in sialyl Lewis X-dependent cancer cells targeting to the lung.

本文言語English
ページ(範囲)4194-4198
ページ数5
ジャーナルCancer Research
62
15
出版ステータスPublished - 2002 8 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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