The correlation between the clinical outcome in patients with esophagealsquamous cell carcinoma and coamplification of the protooncogenesint-2 and h\t-\. which are partially homologous to angiogenesis-inducingfibroblast growth factor, was analyzed retrospectively. Coamplificationof these genes was examined by slot-blot hybridization using DNAsextracted from formalin-fixed and paraffin-embedded blocks of tissues.These tissues were obtained from 107 patients with esophageal squamouscell carcinoma who had undergone radical surgery, int-2/hst-l coamplification greater than 3-fold was observed in the primary tumors of 30 of107 cases (28%), and in the mctastatic lymph nodes of 12 of 40 cases(30%). The cumulative survival rate of patients with int-2/hst-\coamplification in the primary tumors was significantly lower than that of thepatients without coamplification (P < 0.001), and there were no significant differences between the clinicopathological backgrounds of the 2groups, lnt-2 h\t-\ coamplification was also significantly correlated witha high incidence of eventual metastasis in distant organs in these patients.These results suggest that int-2/hsf-\coamplification is a new Biologicalindicator of prognosis and distant organ metastasis in patients withesophageal squamous cell carcinoma.
|出版ステータス||Published - 1991 3|
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