Significance of lymphatic invasion on regional lymph node metastasis in early gastric cancer using LYVE-1 immunohistochemical analysis

Ai Fujimoto, Yukio Ishikawa, Yuri Akishima-Fukasawa, Kinji Ito, Yoshikiyo Akasaka, Seiichi Tamai, Tadaaki Maehara, Hideko Kiguchi, Kentaro Ogata, Chiaki Nishimura, Kazumasa Miki, Toshiharu Ishii

研究成果: Article

22 引用 (Scopus)

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It has been reported that lymphatic invasion is a predictor for lymph node metastasis in early gastric cancer (EGC); however, it has been impossible to differentiate between lymphatic invasion and blood vessel invasion using current staining techniques. We studied the significance of lymphatic invasion on regional lymph node metastasis in EGC by using human lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) antibody, specific to lymphatic vessels, and von Willebrand factor (vWF) antibody, specific to the blood vessels, to clearly distinguish these vascular tissues. EGC tissues were obtained from 66 node-positive and 66 node-negative subjects and were matched by age and sex. These tissues were immunostained with antibodies against LYVE-1 and vWF. Multivariate logistic regression analysis demonstrated that lymphatic invasion was a significant independent predictor for regional lymph node metastasis (odds ratio, 4.667; P = .0094), whereas blood vessel invasion was not. Thus, lymphatic invasion identified by LYVE-1 antibody could predict the existence of regional lymph node metastasis in EGC.

元の言語English
ページ(範囲)82-88
ページ数7
ジャーナルAmerican Journal of Clinical Pathology
127
発行部数1
DOI
出版物ステータスPublished - 2007 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

フィンガープリント Significance of lymphatic invasion on regional lymph node metastasis in early gastric cancer using LYVE-1 immunohistochemical analysis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Fujimoto, A., Ishikawa, Y., Akishima-Fukasawa, Y., Ito, K., Akasaka, Y., Tamai, S., Maehara, T., Kiguchi, H., Ogata, K., Nishimura, C., Miki, K., & Ishii, T. (2007). Significance of lymphatic invasion on regional lymph node metastasis in early gastric cancer using LYVE-1 immunohistochemical analysis. American Journal of Clinical Pathology, 127(1), 82-88. https://doi.org/10.1309/LJQ9G0X8KP17QXP3