Significance of renin-angiotensin system in diabetes mellitus with hypertension

研究成果: Review article査読

抄録

Diabetes mellitus and hypertension frequently occur in the same individual, based upon 'insulin resistance', which is caused by obesity and impairment of secretion of several adipocyte-derived hormones(adipocytokines), including leptin and adiponectin. Insulin resistance and activation of tissue renin-angiotensin system mutually affect each other to promote diabetes mellitus/hypertension and their complications. Especially, renin-angiotensin system in the adipose tissue modulate adipocyte differentiation and adipose tissue mass. Vascular renin-angiotensin system causes endothelial dysfunction and promotes inflammatory process to accelerate atherosclerosis. Blockade of renin-angiotensin system is reasonable for prevention and suppression of diabetes mellitus/hypertension and their complications.

本文言語English
ページ(範囲)1145-1153
ページ数9
ジャーナルNippon rinsho. Japanese journal of clinical medicine
61
7
出版ステータスPublished - 2003 7月
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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