Simple determination of fluoroquinolones with high-performance liquid chromatography

Hiromi Ogino, Ken'ichi Kido, Masao Tsuchiya, Junko Kizu, Seiji Hori

研究成果: Article査読

1 被引用数 (Scopus)

抄録

To use fluoroquinolones effectively and safely, pharmacokinetic/pharmacodynamic (PK/PD) analysis is strongly recommended. The plasma concentration of fluoroquinolones in the patients is necessary for PK/PD analysis. We established new HPLC system with a fluorescent detector enabling us to determine the concentration of 9 fluoroquinolones - ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, pazufloxacin, tosufloxacin - only by changing excitation and emission wave length. We suggest that this is useful for the determination of plasma concentrations of fluoroquinolones in patients and essential for PK/PD analysis.

本文言語English
ページ(範囲)619-622
ページ数4
ジャーナルJapanese Journal of Chemotherapy
53
10
出版ステータスPublished - 2005 10月 1

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)

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