We introduce a new procedure for orthotopic left lung transplantation in rats. First, cuffs are attached to vessels or bronchi in both donors and recipients. Next, the cuffs are anastomosed by interposing pieces of the donor's descending aorta. Anastomosis time is markedly reduced to approximately 10 minutes. Transplantations were completed in 8 rats without technical errors. This rat lung transplantation technique is a straightforward method any surgeon can perform.
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