Simulation study on the balance of glycolytic ATP production and oxidative phosphorylation in embryonic and adult ventricular cells

Hitomi I. Sano, Yasuhiro Naito, Masaru Tomita

研究成果: Conference contribution

抄録

Here, we integrated various characteristics of fetal ventricular cells based on a mathematical model and predicted the contribution of each characteristic to maintenance of intracellular ATP concentration and sarcomere contraction under anoxic conditions. Our simulation results showed that higher glycogen content, higher hexokinase activity, and lower creatine concentration helped to prolong the time that contraction of ventricular cells was maintained under anoxic conditions. The integrated model enabled us to quantitatively assess the contributions of factors related to energy metabolism in ventricular cells.

本文言語English
ホスト出版物のタイトルComputing in Cardiology Conference, CinC 2016
編集者Alan Murray
出版社IEEE Computer Society
ページ249-252
ページ数4
ISBN(電子版)9781509008964
DOI
出版ステータスPublished - 2016 3 1
イベント43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
継続期間: 2016 9 112016 9 14

出版物シリーズ

名前Computing in Cardiology
43
ISSN(印刷版)2325-8861
ISSN(電子版)2325-887X

Other

Other43rd Computing in Cardiology Conference, CinC 2016
国/地域Canada
CityVancouver
Period16/9/1116/9/14

ASJC Scopus subject areas

  • コンピュータ サイエンス(全般)
  • 循環器および心血管医学

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