Simultaneous determination of theophylline and its metabolites by HPLC

H. Kanazawa, J. Kizu, Y. Matsushima

研究成果: Review article査読

8 被引用数 (Scopus)

抄録

A high performance liquid chromatography (HPLC) method has been developed for the simultaneous determination of theophylline and its metabolites, with caffeine and its metabolites. The method is simple and applicable to planning the administration of theophylline. We used a column-switching system in combination with atmospheric pressure chemical ionization liquid chromatography-mass spectrometry (LC-APCI-MS) for the determination of theophylline and its metabolites in biological samples. In the mass spectrum, the molecular ions of these drugs and metabolites were clearly observed as base peaks. The method is sufficiently sensitive and accurate for the pharmacokinetic studies of these drugs.

本文言語English
ページ(範囲)1051-1060
ページ数10
ジャーナルYakugaku Zasshi
120
10
DOI
出版ステータスPublished - 2000 1 1

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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