Simultaneous Microdetermination of Biperiden, Haloperidol, and Trihexyphenidyl in Plasma and Its Application to Pharmacokinetic Analysis after Concomitant Intravenous Administration of the Drugs to Rabbits

Koichi Yokogawa, Emi Nakashima, Fujio Ichimura, Tsukinaka Yamana

研究成果: Article査読

21 被引用数 (Scopus)

抄録

A gas chromatographic method, using a moving precolumn sample injector and a nitrogen-phosphorus detector, is presented for the simultaneous quantitative analysis of biperiden, haloperidol and trihexyphenidyl in plasma. The drugs were extracted from 1 ml of plasma at pH 10.0 with ether, back-extracted into an acidic solution, and reextracted with ether after alkalinization. Diazepam was used as the internal reference standard. Processed standard curves of biperiden, haloperidol, and trihexyphenidyl plasma samples were linear over the concentration range of 1.25–50ng/ml. Recoveries were found to be constant at various spiked doses, and the coefficients of variation were less than 11% for each drug. Plasma concentration-time courses after simultaneous administration of the three drugs to rabbits were analyzed by model-independent moment analysis. The volumes of distribution at the steady state per body weight of biperiden, haloperidol, and trihexyphenidyl were determined to be 18.5, 16.7, and 17.6 1/kg, respectively. Plasma clearances of the three drugs were 89.7, 61.7, and 79.9 ml/min/kg, respectively.

本文言語English
ページ(範囲)4581-4586
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
33
10
DOI
出版ステータスPublished - 1985 1 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

フィンガープリント 「Simultaneous Microdetermination of Biperiden, Haloperidol, and Trihexyphenidyl in Plasma and Its Application to Pharmacokinetic Analysis after Concomitant Intravenous Administration of the Drugs to Rabbits」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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