Single nucleotide polymorphism of interleukin-1β associated with Helicobacter pylori infection in immune thrombocytopenic purpura

T. Satoh, J. P. Pandey, Y. Okazaki, A. Asahi, Y. Kawakami, Y. Ikeda, M. Kuwana

研究成果: Article査読

18 被引用数 (Scopus)

抄録

To examine the role of genetic factors in development of immune thrombocytopenic purpura (ITP) in association with Helicobacter pylori infection, gene polymorphisms within the loci for human leukocyte antigen class II, interleukin (IL)-1β (-511), tumor necrosis factor-β (+252), immunoglobulin (Ig)G1 heavy chain (+643), and Igκ light chain (+573) were determined in 164 adults with ITP and 75 healthy controls. Of these gene polymorphisms, the IL-1β (-511) T allele was less frequently detected in H. pylori-infected than in H. pylori-uninfected (58% vs 81%, P = 0.01, odds ratio = 0.31) ITP patients diagnosed before age 50. These findings suggest that a single nucleotide polymorphism within the IL-1β (-511) may affect susceptibility to early-onset ITP associated with H. pylori infection.

本文言語English
ページ(範囲)353-357
ページ数5
ジャーナルTissue Antigens
73
4
DOI
出版ステータスPublished - 2009 4月 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 生化学
  • 遺伝学

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