"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Eisuke Shimizu, Yoko Ogawa, Hiroyuki Yazu, Naohiko Aketa, Fan Yang, Mio Yamane, Yasunori Sato, Yutaka Kawakami, Kazuo Tsubota

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Tear film breakup time (TFBUT) is an essential parameter used to diagnose dry eye disease (DED). However, a robust method for examining TFBUT in murine models has yet to be established. We invented an innovative device, namely, the "Smart Eye Camera", which addresses several problems associated with existing methods and is capable of evaluating TFBUT in a murine DED model. We compared images taken by existing devices and the Smart Eye Camera in a graft-versus-host disease-related DED murine model. We observed that the quality of the images obtained by the Smart Eye Camera were sufficient for practical use. Moreover, this new technique could be used to obtain measurements for several consecutive ocular phenotypes in a variety of environments. Here, we demonstrate the effectiveness of our new invention in the examination of ocular phenotypes, including TFBUT in a murine model. We highlight the potential for future translational studies adopting the Smart Eye Camera in clinical settings.

本文言語English
論文番号e0215130
ジャーナルPloS one
14
5
DOI
出版ステータスPublished - 2019 5

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)
  • 一般

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