Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

Shota Kurotsu, Taketaro Sadahiro, Ryo Fujita, Hidenori Tani, Hiroyuki Yamakawa, Fumiya Tamura, Mari Isomi, Hidenori Kojima, Yu Yamada, Yuto Abe, Yoshiko Murakata, Tatsuya Akiyama, Naoto Muraoka, Ichiro Harada, Takeshi Suzuki, Keiichi Fukuda, Masaki Ieda

研究成果: Article査読

3 被引用数 (Scopus)

抄録

In this article, Ieda and colleagues showed that a soft matrix, which is comparable with native myocardium, efficiently promoted cardiac reprogramming. This soft matrix enhanced cardiac reprogramming via inhibition of integrin, Rho/ROCK, actomyosin, and YAP/TAZ signaling and subsequent suppression of fibroblast programs, which were activated on conventional rigid substrates, thus demonstrating that mechanotransduction plays a critical role in cardiac reprogramming.

本文言語English
ページ(範囲)612-628
ページ数17
ジャーナルStem cell reports
15
3
DOI
出版ステータスPublished - 2020 9 8

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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