Solid-pseudopapillary neoplasms of the pancreas in men and women: Do they differ?

Yu Takahashi, Nobuyoshi Hiraoka, Kaoru Onozato, Tatsuhiro Shibata, Tomoo Kosuge, Yuji Nimura, Yae Kanai, Setsuo Hirohashi

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Solid-pseudopapillary neoplasms (SPNs) of the pancreas are uncommon and occur preferentially in young women. The question whether the features of SPNs occurring in men differ from those in women has not yet been studied. For a better understanding of the clinicopathological features of SPNs of both sexes, we studied a series of 14 tumors surgically resected at a Japanese hospital within a period of 14 years. This series was composed of seven men and seven women. All these SPNs demonstrated nuclear and cytoplasmic accumulation of β-catenin protein in immunohistochemistry and 86% of them had activating mutations of β-catenin gene. No pancreatic neuroendocrine tumors showed such immunohistochemical findings and genetic alterations. In our series, most SPNs in women showed encapsulation by thick fibrous tissue and massive degenerative changes. Most SPNs in men exhibited solid components without prominent degenerative changes, even though they were of a similar size to those in women. These findings suggest that SPNs in men tend to be a solid mass with slower progression of degenerative changes during their growth compared to that in women. Nuclear accumulation of β-catenin appears to be a useful marker of SPN, which allows male SPNs to be correctly diagnosed despite their less typical features.

本文言語English
ページ(範囲)561-569
ページ数9
ジャーナルVirchows Archiv
448
5
DOI
出版ステータスPublished - 2006 5
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 分子生物学
  • 細胞生物学

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