Soluble form of P-selectin in plasma is elevated in acute lung injury

Fumio Sakamaki, Akitoshi Ishizaka, Makoto Handa, Seitaro Fujishima, Tetsuya Urano, Koichi Sayama, Hidetoshi Nakamura, Minoru Kanazawa, Takeo Kawashiro, Masahiko Katayama, Yasuo Ikeda

研究成果: Article査読

99 被引用数 (Scopus)

抄録

A number of adhesion molecules on neutrophils and the pulmonary capillary endothelium mediate the neutrophil accumulation in the lungs at the onset of adult respiratory distress syndrome or acute lung injury (ALI). P-selectin, located on both vascular endothelial cells and platelets, has been shown to be one of these neutrophil-endothelial cell adhesion molecules. In this study, we measured the soluble form of P-selectin in plasma (PPS) from 19 patients (surviving, 11; deceased, 8) with ALI due to various causes and assessed the clinical significance of this measurement. Twelve healthy subjects and 29 patients with other pulmonary diseases, including idiopathic pulmonary fibrosis (IPF) (n = 8), sarcoidosis (n = 5), pneumonia (n = 8), and sepsis without ALI (n = 8) were also studied for comparison. PPS in patients with ALI (474.5 ± 366.8 ng/ml, mean ± SD) were significantly higher than those in control subjects (98.8 ± 39.7, p < 0.01) and in patients with IPF (210.4 ± 76.6, p < 0.05), sarcoidosis (135.2 ± 71.5, p < 0.05), pneumonia (225.3 ± 81.0, p < 0.05), and sepals without ALI (271.8 ± 46.5, p < 0.05). There was no significant difference in PPS levels between seven patients with and 12 patients without multiple organ failure. Lung injury scores correlated significantly with the PPS level (r = 0.605, p < 0.05). PPS levels of deceased patients with ALI (841.0 ± 252.4) were significantly higher than those of surviving patients with ALI (208.0 ± 109.2, p < 0.01). These findings suggest that PPS levels were elevated in the plasma of patients with ALI, especially in those who subsequently died, as compared with those in patients with other pulmonary disease or sepsis without ALI.

本文言語English
ページ(範囲)1821-1826
ページ数6
ジャーナルAmerican journal of respiratory and critical care medicine
151
6
DOI
出版ステータスPublished - 1995 6月

ASJC Scopus subject areas

  • 呼吸器内科
  • 集中医療医学

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