Solute diffusion through the fibrotic tissue formed around a protective cage system for implantable sensors

Hikaru Ito, Gunawan Setia Prihandana, Kohei Tanimura, Yuki Hori, Orhan Soykan, Ryo Sudo, Norihisa Miki

研究成果: Conference contribution

抄録

Biocompatible packaging is crucial in developing implantable sensors. It should allow solutes of interest to diffuse through while minimizing inflammatory response to the packaging and the sensors. In this study, a cage system made of a metal mesh cylinder surrounded by a polyvinyl alcohol (PVA) sponge material was implanted into rats, and fibrotic tissue was formed around the cage system. We then experimentally investigated the permeation rate of solutes (Na, K and Cl) through the fibrotic tissue using a microfluidic device, and found that diffusion coefficients with respect to all the solutions were on the order of 10-10 m2/s, which increased with the flow rates.

本文言語English
ホスト出版物のタイトルProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
出版社Chemical and Biological Microsystems Society
ページ1267-1269
ページ数3
ISBN(印刷版)9780979806452
出版ステータスPublished - 2012 1 1
イベント16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
継続期間: 2012 10 282012 11 1

出版物シリーズ

名前Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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