Solvolysis of Pyridoxal Hydrochloride in Alcohols

Yoshiko Nagata, Reiko Yoda, Yoshikazu Matsushima

研究成果: Article

4 被引用数 (Scopus)

抄録

HPLC, 1H-NMR, MS and product analysis showed that pyridoxal hydrochloride was solvolyzed in methanol to form pyridoxal monomethylacetal. The reaction followed first order kinetics with the rate constant of 1.45 x 10-4 s-1 at 40 °C. The rate was not appreciably enhanced in the presence of an excess amount of HC1. The reaction was greatly retarded by addition of an equimolar amount of KOH. The results showed that the pyridinium-phenol species of pyridoxal hemiacetal is reactive. The reaction is responsible for the “aging” of alcoholic solutions of pyridoxal, which has caused poor reproducibility of the kinetic data for the formation of Schiff bases with amino acids.

本文言語English
ページ(範囲)1019-1022
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
41
6
DOI
出版ステータスPublished - 1993

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

フィンガープリント 「Solvolysis of Pyridoxal Hydrochloride in Alcohols」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル