Somatic stem cells in the myometrium and in myomas

Tetsuo Maruyama, Masanori Ono, Yasunori Yoshimura

研究成果: Article査読

8 被引用数 (Scopus)

抄録

The human uterus mainly consists of two layers: an inner endometrium and an outer layer, the myometrium, made of smooth muscle. The uterus is characterized by its unique capacity for regeneration. This capacity permits cyclical regeneration and remodeling of the tissue over the course of a woman's reproductive life. During each menstrual cycle, the endometrium regenerates, and the uterus enlarges to make room for fetal growth. This cyclic physiologic pattern suggests that myometrial stem/progenitor cells are present in the tissue and play a role in myometrial functions. Our group (and others) recently characterized and isolated putative stem/progenitor cells in the myometrium. These findings are permitting a better understanding of myometrial physiology and pathology. We review current studies of myometrial stem/progenitor cells and suggestions that, in combination with hypoxia, these cells may contribute to uterine remodeling during pregnancy and the formation of myomas.

本文言語English
ページ(範囲)77-81
ページ数5
ジャーナルSeminars in Reproductive Medicine
31
1
DOI
出版ステータスPublished - 2013

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生殖医学
  • 内分泌学
  • 産婦人科学
  • 生理学(医学)

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