Space in systems biology of signaling pathways - Towards intracellular molecular crowding in silico

Kouichi Takahashi, Satya Nanda Vel Arjunan, Masaru Tomita

研究成果: Short survey査読

185 被引用数 (Scopus)

抄録

How cells utilize intracellular spatial features to optimize their signaling characteristics is still not clearly understood. The physical distance between the cell-surface receptor and the gene expression machinery, fast reactions, and slow protein diffusion coefficients are some of the properties that contribute to their intricacy. This article reviews computational frameworks that can help biologists to elucidate the implications of space in signaling pathways. We argue that intracellular macromolecular crowding is an important modeling issue, and describe how recent simulation methods can reproduce this phenomenon in either implicit, semi-explicit or fully explicit representation.

本文言語English
ページ(範囲)1783-1788
ページ数6
ジャーナルFEBS Letters
579
8
DOI
出版ステータスPublished - 2005 3月 21

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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