TY - JOUR
T1 - Spatial Frequency-Based Characterization of Disturbance Rejection in Molecular Communication Systems
AU - Kotsuka, Taishi
AU - Hori, Yutaka
N1 - Funding Information:
This work was supported in part by the Okawa Foundation Research Grant under Grant 16-10, and in part by the Japan Society for the Promotion of Science KAKENHI under Grant JP18H01464
Publisher Copyright:
© 2015 IEEE.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - In nature, bacteria regulate their population-level behavior using a molecular communication (MC) mechanism mediated by signaling molecules that diffuse between cells. The MC mechanism has been actively used in recent synthetic biology to transmit the state of genetic circuits, but it is not clear how the cell-cell communication channel affects the performance of the MC systems. In this paper, we propose a computational method to analyze the impact of disturbance on cell-cell MC systems based on a general reaction-diffusion model of MC systems. More specifically, we present an algebraic equation to compute the performance metric of the rejection of disturbance for each spatial frequency. Finally, we illustrate the proposed method by analyzing an activator-repressor-diffuser network and discuss the effect of the diffusive communication on disturbance response.
AB - In nature, bacteria regulate their population-level behavior using a molecular communication (MC) mechanism mediated by signaling molecules that diffuse between cells. The MC mechanism has been actively used in recent synthetic biology to transmit the state of genetic circuits, but it is not clear how the cell-cell communication channel affects the performance of the MC systems. In this paper, we propose a computational method to analyze the impact of disturbance on cell-cell MC systems based on a general reaction-diffusion model of MC systems. More specifically, we present an algebraic equation to compute the performance metric of the rejection of disturbance for each spatial frequency. Finally, we illustrate the proposed method by analyzing an activator-repressor-diffuser network and discuss the effect of the diffusive communication on disturbance response.
KW - Molecular communication
KW - biological control systems
KW - control theory
KW - robust control
UR - http://www.scopus.com/inward/record.url?scp=85107176221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85107176221&partnerID=8YFLogxK
U2 - 10.1109/TMBMC.2021.3083726
DO - 10.1109/TMBMC.2021.3083726
M3 - Article
AN - SCOPUS:85107176221
SN - 2332-7804
VL - 8
SP - 36
EP - 43
JO - IEEE Transactions on Molecular, Biological, and Multi-Scale Communications
JF - IEEE Transactions on Molecular, Biological, and Multi-Scale Communications
IS - 1
ER -