Spatiotemporal measurement of tumor oxygenation reveals repeat hypoxic phenomenon in mice

Ryo Yamada, Hirohisa Horinouch, Kosuke Tsukada

研究成果: Conference contribution

抄録

Tumor hypoxia is considered a potential therapeutic problem because it reduces the effects of radiation therapy. Clinical experience has shown that long-term tumor oxygenation cannot be achieved with oxygen inhalation, but the mechanisms behind this phenomenon remain unknown. In this study, we designed an optical system for evaluating spatiotem-poral changes in tissue oxygen tension (pO 2) by phosphorescence quenching. The system can measure continuous changes in pO 2 at a fixed point and can also perform two-dimensional mapping of pO 2 in any part of the tumor tissue. We implanted tumor tissue in a dorsal skinfold chamber of C57BL/6 mice and observed tumor growth. After the tumor attained a diameter of 2 mm, the mice received oxygen inhalation and pO 2 was measured. Tumor pO 2 increased after inhalation but the oxygen level was not maintained despite continuous inhalation of pure oxygen; the tumor returned to a hypoxic state. These results mimic the clinical experience of oxygen inhalation treatment in radiation therapy. Our system reproduces the repeat hypoxic phenomenon in a murine tumor model and can be used to determine the mechanisms of oxygen metabolism in tumors.

本文言語English
ホスト出版物のタイトル33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
ページ5965-5968
ページ数4
DOI
出版ステータスPublished - 2011
イベント33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
継続期間: 2011 8 302011 9 3

出版物シリーズ

名前Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN(印刷版)1557-170X

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period11/8/3011/9/3

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

フィンガープリント 「Spatiotemporal measurement of tumor oxygenation reveals repeat hypoxic phenomenon in mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル