Spatiotemporal patterns of Musashil expression during inner ear development

Hirofumi Sakaguchi, Takeshi Yaoi, Toshihiro Suzuki, Hideyuki Okano, Yasuo Hisa, Shinji Fushiki

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Musashil (Msi I) is an RNA binding protein associated with asymmetric cell divisions in neural progenitor cells.To investigate the involvement of MsiI in the inner ear development, we studied the expression of MsiI in mouse inner ears with RT-PCR and immunohistochemistry. Immunohistochemistry revealed that MsiI was expressed in all otocyst cells at embryonic day (E) 10 and 12. MsiI immunoreactivity became lost in hair cells after E14 in vestibule and after E16 in cochlea, whereas it persisted in supporting cells until adulthood. The subcellular localization of MsiI changed from "cytoplasmic predominance" to "nuclear predominance" during the first 2 weeks after birth. The present data suggested that Msi may play a role in inner ear development.

本文言語English
ページ(範囲)997-1001
ページ数5
ジャーナルNeuroReport
15
6
DOI
出版ステータスPublished - 2004 4月 29

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Spatiotemporal patterns of Musashil expression during inner ear development」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル