Specification and epigenetic programming of the human germ line

Walfred W.C. Tang, Toshihiro Kobayashi, Naoko Irie, Sabine Dietmann, M. Azim Surani

研究成果: Review article査読

230 被引用数 (Scopus)

抄録

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a unique gene regulatory network in germline-competent cells for PGC specification. This network also initiates comprehensive epigenome resetting, including global DNA demethylation and chromatin reorganization. Mouse germline development has been studied extensively, but the extent to which such knowledge applies to humans was unclear. Here, we review the latest advances in human PGC specification and epigenetic reprogramming. The overall developmental dynamics of human and mouse germline cells appear to be similar, but there are crucial mechanistic differences in PGC specification, reflecting divergence in the regulation of pluripotency and early development.

本文言語English
ページ(範囲)585-600
ページ数16
ジャーナルNature Reviews Genetics
17
10
DOI
出版ステータスPublished - 2016 10月 1
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)

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