Spermatozoal RNA profiling towards a clinical evaluation of sperm quality

研究成果: Comment/debate査読

10 被引用数 (Scopus)

抄録

Human spermatozoal RNAs were recently profiled using microarrays and explored as clinical markers of male infertility. An appropriate study design with a considerable number of biological replicates (sperm samples) is necessary to validate the accuracy and reproducibility of these microarray data. If the genes identified as sperm quality markers by microarray studies are successfully attributed to the pathogenesis of male infertility, then the microarray strategy may be used as a clinical diagnostic tool for male infertility. On the other hand, spermatozoal RNAs may contain not only remnant RNAs after spermatogenesis, but also RNAs that may contribute extragenomically to early embryonic development. Therefore, spermatozoal RNA profiling may enable a better understanding of what is contributed to the oocyte by sperm, in addition to their genome, to facilitate early embryonic development.

本文言語English
ページ(範囲)103-105
ページ数3
ジャーナルReproductive BioMedicine Online
22
2
DOI
出版ステータスPublished - 2011 2

ASJC Scopus subject areas

  • 生殖医学
  • 産婦人科学
  • 発生生物学

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