Spindle-shaped constriction and propagated dilation of arterioles during cortical spreading depression

Takashi Osada, Minoru Tomita, Norihiro Suzuki

研究成果: Article査読

13 被引用数 (Scopus)

抄録

A dual illumination technique was used to examine the behavior of parenchymal arterioles of the cortex during cortical spreading depression in six cats. K+ produced a wave-ring spread of optical density changes concentrically from the injection site. At locations where the wave was passing, arterioles first constricted at one or two spots (55±43% of control), forming a spindle-shape in the early phase of cortical spreading depression, and then markedly dilated (155±57% of control) within 1 min. The dilation started at the constricted spots, propagated bidirectionally and finally resulted in full-length dilation of the arteriole. Although it varied in magnitude and time-course, this arteriolar behavior was observed in all six cats. Despite these changes, no associated downstream tissue microvascular flow changes were discernable.

本文言語English
ページ(範囲)1365-1368
ページ数4
ジャーナルNeuroReport
17
12
DOI
出版ステータスPublished - 2006 8 1

ASJC Scopus subject areas

  • Neuroscience(all)

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